Ait-Oufella, Hafid

Year of Birth: 
+33 6 11 01 19 40

Hafid Ait-Oufella, MD.PhD
Inserm U970, PARCC
56, rue Leblanc, 75015 Paris, France
UniversitÈ Paris Descartes,
Paris 5


1994 : Bachelorís degree
1994 : 2000: Medical school
2000-2008 : Medical resident, specialist in cardiovascular diseases and intensive medicine, Paris public Hospitals, France
2004-2008 : PhD student
2008 : PhD in Vascular Biology, Thrombosis and Haemostasis, Paris ,France
2009 : MD, Doctor in medicine, specialist in cardiovascular medicine and Intensive medicine
2008-2010 : fellow, Intensive Unit Care, Paris, public Hospitals, Paris, france
Since 2010 : associated professor Intensive Unit Care, Paris, public Hospitals, Paris, France
INSERM U970, Paris Cardiovascular Research Center


Basic research : Vascular biology (atherosclerosis and aneuvrysm) and immuno-inflammatory response
Clinical research: Endothelial dysfunction and septic shock


AIT-OUFELLA Hafid (France)
After a medical formation specialized in cardiovascular medicine and a PhD in vascular biology, I decided to combine clinical activity and basic research. Ten years ago, I joined Pr Alain Tedgui and Pr Ziad Mallat (INSERM U689 then U970) to form a research group on cardiovascular diseases and atherosclerosis that represent the leading cause of death in developed countries. An increasing body of evidence indicates that the immune system plays a major role in modulating the atherogenic process. In the last decade, my group has been actively involved in the study of the cellular and molecular pathways implicated in the regulation of the immuno-inflammatory response in atherosclerosis. Particularly, we have pointed to new major chemokine pathways involved in monocyte/macrophage recruitment and accumulation into atherosclerotic lesions, and identified a critical role for the regulatory arm of the adaptive T cell response in the control of lesion development. More recently, we have shown that defective clearance of apoptotic cells impairs the regulatory immune response in atherosclerosis and accelerates lesion development, suggesting an important interplay between innate and adaptive immunity in promoting lesion development and progression. Current research activities address the relation between autoimmune diseases and atherosclerosis, and the role of the regulatory immune response in the prevention and/or treatment of plaque vulnerability.

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